Program Schedule
The Globalization of Pharmaceutics Education Network (GPEN) Executive Committee and the Department of Pharmacy at the National University of Singapore are pleased to announce the 12th biennial GPEN conference in Singapore. The softcopy of the conference proceedings is available here. Scientific abstracts are also available by clicking on the respective presentation code in the program below.
Hide all events
orMain day 1, Wed, 26th Sep
Venue: Kent Ridge Guild House
Time | Event |
---|---|
2:00 PM - 4:30 PM | Registration |
5:00 PM - 5:15 PM | Welcome address by Prof. Kenneth AUDUS Chair, Globalization of Pharmaceutics Education Network Professor and Dean, School of Pharmacy University of Kansas |
5:15 PM - 5:30 PM | Opening remarks by Guest of Honour Prof. Freddy BOEY Senior Vice President (Graduate Education & Research Translation) National University of Singapore |
5:30 PM - 6:30 PM | Keynote Lecture by Prof. Patrick J. CASEY Professor and Senior Vice Dean, Research Duke-NUS Medical School |
6:30 PM - 8:00 PM | Welcome Reception |
Main day 2, Thu, 27th Sep
Venue: Shaw Foundation Alumni House
- Podium session 1: Nanoparticles in drug delivery
Code Time Title Presenter S1 8:00 AM Young´s moduli of gelatin nanoparticles and how their mechanical properties influence the in vitro fate
AbstractAgnes-Valencia WEIß S2 8:20 AM Isolation of exosomes for drug delivery applications
AbstractBritta HETTICH S3 8:40 AM Synthesis, characterization, and in vitro and in vivo evaluation of biodegradable silica nanoparticles
AbstractPouya HADIPOUR S4 9:00 AM The application of light scattering techniques to investigate surface distribution of cell-penetrating peptides on polymeric nanoparticles
AbstractSarah STRECK 9:20 AM Coffee Break and Poster Session I - Podium session 2: Lipid-based drug delivery
Code Time Title Presenter S5 10:10 AM Tetraether liposomes loaded with hypericin for photodynamic therapy of ovarian cancer cells
AbstractNikola PLENAGL S6 10:30 AM Improved oral bioavailability by supersaturated silica-lipid hybrid formulations
AbstractHayley SCHULTZ S7 10:50 AM A digestion/permeation model based on artificial membranes for studies of performance of lipid-based formulations
AbstractOliver HEDGE S8 11:10 AM Cyclodextrin complexation as a tool to allow repurposing of chlorpromazine for treatment of acute myeloid leukemia
AbstractZhiqiang WANG S9 11:30 AM Fabrication of 3D-printed biocompatible hydrogel patch for the local delivery of PEGylated liposomal doxorubicin
AbstractJin LIU 11:50 AM Lunch - Podium session 3: Drug delivery and Formulation
Code Time Title Presenter S10 1:10 PM Hydrogels releasing nucleic acid-loaded polyplexes
AbstractLies FLIERVOET S11 1:30 PM Bioresponsive self-assembled DNA hydrogels for antimicrobial peptide loading and therapy
AbstractSybil OBUOBI S12 1:50 PM Inkjet-based 3D printing of solid oral dosage manufacturing
AbstractKoyel SEN S13 2:10 PM Triple HIV drug combination and lipid excipients form stable solid state interactions leading to an ordered matrix for enhanced drug deliveryAbstract Jesse YU S14 2:30 PM Treatment with vernix caseosa based formulation alters the skin lipid composition of regenerated stratum corneum
AbstractWalter BOITEN 2:50 PM Coffee Break and Poster Session II - Podium session 4: Drug delivery and Formulation
Code Time Title Presenter S15 3:40 PM Probing compression and storage induced surface crystallization with rapid multi-modal nonlinear optical imaging
AbstractDunja NOVAKOVIC S16 4:00 PM Probing miscibility and mobility in lyophilized protein formulations using solid-state nuclear magnetic resonance spectroscopy
AbstractAshley LAY S17 4:20 PM Investigation of drug dissolution and absorption from low-density inhalation budesonide formulations in a cell culture integrating impactor system
AbstractUrsula THORMANN S18 4:40 PM Impact of amorphization strategy and drug loading on dissolution rate of spray dried indomethacin
AbstractYongquan LI - GPEN networking event: Cultural Night
Time Event 5:00 PM Bus transfer to Satay by the Bay - Gardens by the Bay 6:00 PM Cultural Night @ Satay by the Bay - Gardens by the Bay
Main day 3, Fri, 28th Sep
Venue: Shaw Foundation Alumni House
- Podium session 5: Targeted drug delivery and pharmacogenomics
Code Time Title Presenter S20 8:00 AM Development of a nanostructured RNA/DNA adjuvant targeting Toll-like receptor 7/8
AbstractFusae KOMURA S21 8:20 AM Tumor microenvironment sub-type immune cells precise delivery by extravasation-oriented targeting-ligand reemerge strategy: the first step on the way to effective cancer immunotherapy
AbstractTianqi WANG S22 8:40 AM Characterizing patient-derived induced neural stem cells as a drug delivery platform for glioblastoma
AbstractShaye HAGLER S23 9:00 AM Genome-wide analyses associate variants in Rho GTPase signaling pathways with microtubule targeting agent-induced sensory peripheral neuropathy
AbstractKatherina CHUA S24 9:20 AM Effect of ABCB1 haplotypes on tacrolimus disposition in heart transplant recipients
AbstractKris ORESCHAK 9:40 AM Coffee Break and Poster Session I - Podium session 6: Pharmacokinetics
Code Time Title Presenter S25 10:30 AM Metabolomic/proteomic analysis of orphan transporter monocarboxylate transporter 6 (MCT6): Evidence of a role in lipid metabolism
AbstractRobert JONES S26 10:50 AM Quantification of postmenopausal osteoporosis population: An system pharmacology approach using bisphosphonates.
AbstractYi Ting (Kayla) LIEN S27 11:10 AM Investigation of endogenous substrates of OCT2 as surrogate biomarker for the prediction of transporter-mediated drug-drug interaction
AbstractTakeshi MIYAKE S28 11:30 AM Quantification of 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids helps to understand the intraluminal drug behavior following the oral intake of Sporanox®
AbstractPhilippe BERBEN S29 11:50 AM A co-perfused in vivo absorption model to probe the simultaneous digestion and drug absorption process from lipid-based formulations
AbstractEstelle SUYS 12:10 AM Lunch - Podium session 7: Proteomics and biomarkers
Code Time Title Presenter S30 1:30 PM Quantitative proteomics-based characterization of apical and basolateral membrane protein localization in human retinal pigmental epithelial cells
AbstractKazuki SATO S31 1:50 PM Isolation and characterization of liver-derived exosomes by liver marker protein asialoglycoprotein-1 (ASGR1) and proteomic Analysis
AbstractLaura DRBOHLAV S32 2:10 PM Fibrillation kinetics of therapeutic peptides by hydrogen/deuterium exchange mass spectrometry (HDX-MS)
AbstractHarshil RENAWALA S33 2:30 PM Evaluation of paraoxonase-1 activity in the synovial fluid of osteoarthritis patients
AbstractDaniel AKATWIJUKA 2:50 PM Coffee Break and Poster Session II - Podium session 8: Signaling pathways
Code Time Title Presenter S34 3:40 PM HSPG2/perlecan as a therapeutic target in metastatic cancers
AbstractVidhi KHANNA S35 4:00 PM Reversal of fatty liver by peripheral CB1 receptor blockade Is SIRT1/PPARα dependent
AbstractShahar AZAR S36 4:20 PM Impact of the canonical Wnt signaling pathway on blood-brain barrier (BBB) phenotype
AbstractMarlyn LAKSITORINI - GPEN networking event: Gala Dinner
Time Event 4:40 PM Bus transfer to Flyer Event Hall - Singapore Flyer 6:30 PM Gala Dinner @ Singapore Flyer
Short courses, Sat, 29th Sep
Venue: S16, Faculty of Science
Time | Event |
---|---|
8:00 AM - 8:20 AM | Arrival and luggage storage |
8:30 AM - 12:10 PM | Short courses 1-6 (details below) |
12:20 PM - 1:30 PM | Lunch |
1:30 PM - 2:00 PM | Closing and award ceremony |
- Challenges and progress in drug delivery: Prodrugs and macromolecules
Leaders:
Prof. Teruna SIAHAAN, University of Kansas
Prof. Donald MILLER, University of Manitoba
*Titles to-be-confirmed (TBC)
Code Time Title Presenter Affiliation C11 8:30 AM General overview of approaches for prodrug and macromolecule delivery across biological barriers Teruna SIAHAAN University of Kansas C12 9:05 AM Prodrug approaches for oral absorption Patrick AUGUSTIJNS KU Leuven C13 9:40 AM Nanocage therapeutics mediating immune checkpoint blockade awakens immunity against cancer with an immunogenic cell death (ICD)-inducing doxorubicin prodrug
AbstractNa Kyeong LEE
(Student)Seoul National University 10:00 AM Tea break C14 10:20 AM Prodrug and macromolecule approaches for delivering drugs to the brain Donald MILLER University of Manitoba C15 10:55 AM Using Exosomes as Natural Carriers for Nucleic Acid Transfer: An Activity-Composition Analysis Juliane NGUYEN University of Buffalo C16 11:30 AM Reprogrammed Exosomes as a Novel Immunotherapy for Breast Cancer
AbstractXiaojing SHI
(Student)University of Southern California C17 11:50 AM Design and In Vitro/In Vivo Evaluation of LyP-1 Containing SMEDDS for Active Targeting in Breast Cancer Therapy
AbstractSelin Seda TIMUR
(Postdoc)Hacettepe University - Optimizing drug-like properties in discovery and development
Leader: Prof. Michael HAGEMAN, University of KansasCode Time Title Presenter Affiliation C21 8:30 AM Effect of protein binding on hepatic clearance, intracellular concentration and IC50 predictions Ken BROUWER BioIVT C22 9:05 AM Solubility, biopharmaceutical profiling and formulate-ability: computational tools for assessment during the drug discovery stage Christel BERGSTRÖM
Uppsala University C23 9:40 AM Dodecylated and non-dodecylated polycations as promising siRNA complexing agents for skin diseases treatment
AbstractMarcelo KRAVICZ
(Student)University of Sao Paulo 10:00 AM Tea break C24 10:20 AM Optimizing for developability and maximizing oral exposure in discovery Michael HAGEMAN University of Kansas C25 10:55 AM Processing-induced phase transformations Raj SURYANARAYANAN University of Minnesota C26 11:30 AM Characterization of the PEGylated-Functional Upstream Domain Peptide (PEG-FUD): a Potent Fibronectin Assembly Inhibitor with Potential as an Anti-fibrotic Therapeutic
AbstractPawel ZBYSZYNSKI
(Student)University of Wisconsin-Madison C27 11:50 AM Chloroquine Nanoparticles Improve Biodistribution and Sensitize Pancreatic Cancer to Oxaliplatin and Radiation Therapy
AbstractRichard SLEIGHTHOLM
(Student)University of Nebraska Medical Center - Stability and formulation of biomolecules: Proteins and vaccines
Leader: Prof. Christian SCHÖNEICH, University of KansasCode Time Title Presenter Affiliation C31 8:30 AM The ever increasing complexity of protein degradation pathways Christian SCHÖNEICH University of Kansas C32 9:05 AM Forced degradation of biologicals: why, how and wow Wim JISKOOT Leiden University C33 9:40 AM Cationic microparticle carrier system as adjuvant approach for pandemic influenza vaccines; proof-of-principle with adsorbed whole inactivated H5N1 influenza
AbstractCeline LEMOINE
(Student)University of Geneva 10:00 AM Tea break C34 10:20 AM Biosimilarity under stress: a forced degradation study of Remicade and Remsima Anna SCHWENDEMAN University of Michigan C35 10:55 AM Synthetic high-density lipoprotein nanodiscs for personalized vaccination against glioblastoma multiforme
AbstractLindsay SCHEETZ
(Student)University of Michigan C36 11:15 AM Functional evaluation of mucoadhesive liposome aiming oral delivery of peptide drugs
AbstractKeiko MINAMI
(Student)Setsunan University C37 11:35 AM Synthesis of functionalised dendritic silica nanoparticles for delivery of anti-diabetic peptide
AbstractMuhammad Mustafa ABEER
(Student)University of Queensland - Application of computational analysis in drug discovery and development
Leader: Prof. Yu Zong CHEN, National University of SingaporeCode Time Title Presenter Affiliation C41 8:30 AM Artificial Intelligence and Drug Discovery Yu Zong CHEN National University of Singapore C42 9:15 AM Computational strategies in search for drug design scaffolds from natural products Habibah A WAHAB Universiti Sains Malaysia 10:00 AM Tea break C43 10:20 AM High-Content Analysis of Constitutive Androstane Receptor Nuclear Translocation Accurately Identifies Physiologically-Relevant Activators
AbstractBryan MACKOWIAK
(Student)University of Maryland C44 10:40 AM Computational modelling of protein-ligand interactions, applied to ligand discovery and function mechanism studies Hao FAN Bioinformatics Institute, A*STAR C45 11:25 AM Development of Novel Method to Analyze Transcriptome Profile Data Tadahaya MIZUNO University of Tokyo - Population pharmacokinetic modeling and its clinical application
Leader: Prof. Paul Chi Lui HO, National University of SingaporeCode Time Title Presenter Affiliation C51 8:30 AM Full Covariates Modelling using Random effects to overcome the bias of covariate selection Hwi-yeol YUN Chungnam National University C52 9:05 AM Population Pharmacokinetic (PK) - Pharmacogenomic (PG) - Pharmacodynamic (PD) modeling of inhaled budesonide/formoterol combination in Korean asthmatics
AbstractJunyeong KIM (Student) Chungnam National University C53 9:25 AM R for PK simulation Cheng-Cai TANG Lilly Centre for Clinical Pharmacology Pte Ltd 10:00 AM Tea break C54 10:20 AM Modern tools to enhance clinical utility of modelling and simulation Lai-San THAM Lily Centre for Clinical Pharmacology Pte Ltd C55 10:55 AM Identifying clinically relevant sources of variability: The clopidogrel challenge Stephan SCHMIDT University of Florida C56 11:30 AM Dried blood spots for population pharmacokinetic studies of antiepileptic drugs and phenotyping drug resistant epilepsy Paul Chi Lui HO National University of Singapore - Mechanistic and quantitative modeling in pharmacology and toxicology
Leader: Prof. Eric Chun Yong CHAN, National University of SingaporeCode Time Title Presenter Affiliation C61 8:30 AM Introduction on mechanistic and quantitative modeling in pharmacology and toxicology Eric CHAN National University of Singapore C62 9:00 AM Development, validation and application of model to guide complex injectable drug-combination products Rodney HO University of Washington C63 9:40 AM A comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically-based pharmacokinetic modelling
AbstractFabian JUNG (Student) Goethe University Frankfurt 10:00 AM Tea break C64 10:20 AM Mechanistic modeling to evaluate bile acid-mediated drug-induced liver injury and hepatic transporter interactions Kim BROUWER University of North Carolina Chapel Hill C66 11:00 AM Extended pharmacokinetic model of the rabbit eye for intravitreal and intracameral injections of macromolecules: quantitative analysis of anterior and posterior elimination pathways
AbstractMarko LAMMINSALO (Student) University of Eastern Finland C67 11:20 AM Integrating host-pathogen interactions: A systems-based approach to address antimicrobial resistance Gauri RAO University of North Carolina Chapel Hill