Program Schedule

The Globalization of Pharmaceutics Education Network (GPEN) Executive Committee and the Department of Pharmacy at the National University of Singapore are pleased to announce the 12th biennial GPEN conference in Singapore. The softcopy of the conference proceedings is available here. Scientific abstracts are also available by clicking on the respective presentation code in the program below.

Show or Hide all events

Main day 1, Wed, 26th Sep

Venue: Kent Ridge Guild House

TimeEvent
2:00 PM - 4:30 PMRegistration
5:00 PM - 5:15 PMWelcome address by Prof. Kenneth AUDUS
Chair, Globalization of Pharmaceutics Education Network
Professor and Dean, School of Pharmacy
University of Kansas
5:15 PM - 5:30 PMOpening remarks by Guest of Honour
Prof. Freddy BOEY
Senior Vice President (Graduate Education & Research Translation)
National University of Singapore
5:30 PM - 6:30 PMKeynote Lecture by
Prof. Patrick J. CASEY
Professor and Senior Vice Dean, Research
Duke-NUS Medical School
6:30 PM - 8:00 PMWelcome Reception

Main day 2, Thu, 27th Sep

Venue: Shaw Foundation Alumni House

  • Podium session 1: Nanoparticles in drug delivery
    CodeTimeTitlePresenter
    S18:00 AMYoung´s moduli of gelatin nanoparticles and how their mechanical properties influence the in vitro fate
    Abstract
    Agnes-Valencia WEIß
    S28:20 AMIsolation of exosomes for drug delivery applications
    Abstract
    Britta HETTICH
    S38:40 AMSynthesis, characterization, and in vitro and in vivo evaluation of biodegradable silica nanoparticles
    Abstract
    Pouya HADIPOUR
    S49:00 AMThe application of light scattering techniques to investigate surface distribution of cell-penetrating peptides on polymeric nanoparticles
    Abstract
    Sarah STRECK
    9:20 AMCoffee Break and Poster Session I
  • Podium session 2: Lipid-based drug delivery
    CodeTimeTitlePresenter
    S510:10 AMTetraether liposomes loaded with hypericin for photodynamic therapy of ovarian cancer cells
    Abstract
    Nikola PLENAGL
    S610:30 AMImproved oral bioavailability by supersaturated silica-lipid hybrid formulations
    Abstract
    Hayley SCHULTZ
    S710:50 AMA digestion/permeation model based on artificial membranes for studies of performance of lipid-based formulations
    Abstract
    Oliver HEDGE
    S811:10 AMCyclodextrin complexation as a tool to allow repurposing of chlorpromazine for treatment of acute myeloid leukemia
    Abstract
    Zhiqiang WANG
    S911:30 AMFabrication of 3D-printed biocompatible hydrogel patch for the local delivery of PEGylated liposomal doxorubicin
    Abstract
    Jin LIU
    11:50 AMLunch
  • Podium session 3: Drug delivery and Formulation
    CodeTimeTitlePresenter
    S101:10 PMHydrogels releasing nucleic acid-loaded polyplexes
    Abstract
    Lies FLIERVOET
    S111:30 PMBioresponsive self-assembled DNA hydrogels for antimicrobial peptide loading and therapy
    Abstract
    Sybil OBUOBI
    S121:50 PMInkjet-based 3D printing of solid oral dosage manufacturing
    Abstract
    Koyel SEN
    S132:10 PMTriple HIV drug combination and lipid excipients form stable solid state interactions leading to an ordered matrix for enhanced drug deliveryAbstractJesse YU
    S142:30 PMTreatment with vernix caseosa based formulation alters the skin lipid composition of regenerated stratum corneum
    Abstract
    Walter BOITEN
    2:50 PMCoffee Break and Poster Session II
  • Podium session 4: Drug delivery and Formulation
    CodeTimeTitlePresenter
    S153:40 PMProbing compression and storage induced surface crystallization with rapid multi-modal nonlinear optical imaging
    Abstract
    Dunja NOVAKOVIC
    S164:00 PMProbing miscibility and mobility in lyophilized protein formulations using solid-state nuclear magnetic resonance spectroscopy
    Abstract
    Ashley LAY
    S174:20 PMInvestigation of drug dissolution and absorption from low-density inhalation budesonide formulations in a cell culture integrating impactor system
    Abstract
    Ursula THORMANN
    S184:40 PMImpact of amorphization strategy and drug loading on dissolution rate of spray dried indomethacin
    Abstract
    Yongquan LI
  • GPEN networking event: Cultural Night
    TimeEvent
    5:00 PMBus transfer to Satay by the Bay - Gardens by the Bay
    6:00 PMCultural Night @ Satay by the Bay - Gardens by the Bay

Main day 3, Fri, 28th Sep

Venue: Shaw Foundation Alumni House

  • Podium session 5: Targeted drug delivery and pharmacogenomics
    CodeTimeTitlePresenter
    S208:00 AMDevelopment of a nanostructured RNA/DNA adjuvant targeting Toll-like receptor 7/8
    Abstract
    Fusae KOMURA
    S218:20 AMTumor microenvironment sub-type immune cells precise delivery by extravasation-oriented targeting-ligand reemerge strategy: the first step on the way to effective cancer immunotherapy
    Abstract
    Tianqi WANG
    S228:40 AMCharacterizing patient-derived induced neural stem cells as a drug delivery platform for glioblastoma
    Abstract
    Shaye HAGLER
    S239:00 AMGenome-wide analyses associate variants in Rho GTPase signaling pathways with microtubule targeting agent-induced sensory peripheral neuropathy
    Abstract
    Katherina CHUA
    S249:20 AMEffect of ABCB1 haplotypes on tacrolimus disposition in heart transplant recipients
    Abstract
    Kris ORESCHAK
    9:40 AMCoffee Break and Poster Session I
  • Podium session 6: Pharmacokinetics
    CodeTimeTitlePresenter
    S2510:30 AMMetabolomic/proteomic analysis of orphan transporter monocarboxylate transporter 6 (MCT6): Evidence of a role in lipid metabolism
    Abstract
    Robert JONES
    S2610:50 AMQuantification of postmenopausal osteoporosis population: An system pharmacology approach using bisphosphonates.
    Abstract
    Yi Ting (Kayla) LIEN
    S2711:10 AMInvestigation of endogenous substrates of OCT2 as surrogate biomarker for the prediction of transporter-mediated drug-drug interaction
    Abstract
    Takeshi MIYAKE
    S2811:30 AMQuantification of 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids helps to understand the intraluminal drug behavior following the oral intake of Sporanox®
    Abstract
    Philippe BERBEN
    S2911:50 AMA co-perfused in vivo absorption model to probe the simultaneous digestion and drug absorption process from lipid-based formulations
    Abstract
    Estelle SUYS
    12:10 AMLunch
  • Podium session 7: Proteomics and biomarkers
    CodeTimeTitlePresenter
    S301:30 PMQuantitative proteomics-based characterization of apical and basolateral membrane protein localization in human retinal pigmental epithelial cells
    Abstract
    Kazuki SATO
    S311:50 PMIsolation and characterization of liver-derived exosomes by liver marker protein asialoglycoprotein-1 (ASGR1) and proteomic Analysis
    Abstract
    Laura DRBOHLAV
    S322:10 PMFibrillation kinetics of therapeutic peptides by hydrogen/deuterium exchange mass spectrometry (HDX-MS)
    Abstract
    Harshil RENAWALA
    S332:30 PMEvaluation of paraoxonase-1 activity in the synovial fluid of osteoarthritis patients
    Abstract
    Daniel AKATWIJUKA
    2:50 PMCoffee Break and Poster Session II
  • Podium session 8: Signaling pathways
    CodeTimeTitlePresenter
    S343:40 PMHSPG2/perlecan as a therapeutic target in metastatic cancers
    Abstract
    Vidhi KHANNA
    S354:00 PMReversal of fatty liver by peripheral CB1 receptor blockade Is SIRT1/PPARα dependent
    Abstract
    Shahar AZAR
    S364:20 PMImpact of the canonical Wnt signaling pathway on blood-brain barrier (BBB) phenotype
    Abstract
    Marlyn LAKSITORINI
  • GPEN networking event: Gala Dinner
    TimeEvent
    4:40 PMBus transfer to Flyer Event Hall - Singapore Flyer
    6:30 PMGala Dinner @ Singapore Flyer

Short courses, Sat, 29th Sep

Venue: S16, Faculty of Science

TimeEvent
8:00 AM - 8:20 AMArrival and luggage storage
8:30 AM - 12:10 PMShort courses 1-6 (details below)
12:20 PM - 1:30 PMLunch
1:30 PM - 2:00 PMClosing and award ceremony
The following concurrent short courses will be available, with exact venue to be announced at a later date.

  1. Challenges and progress in drug delivery: Prodrugs and macromolecules
    Leaders:
    Prof. Teruna SIAHAAN, University of Kansas
    Prof. Donald MILLER, University of Manitoba
    *Titles to-be-confirmed (TBC)
    CodeTimeTitlePresenterAffiliation
    C118:30 AMGeneral overview of approaches for prodrug and macromolecule delivery across biological barriersTeruna SIAHAANUniversity of Kansas
    C129:05 AMProdrug approaches for oral absorptionPatrick AUGUSTIJNSKU Leuven
    C139:40 AMNanocage therapeutics mediating immune checkpoint blockade awakens immunity against cancer with an immunogenic cell death (ICD)-inducing doxorubicin prodrug
    Abstract
    Na Kyeong LEE
    (Student)
    Seoul National University
    10:00 AMTea break
    C1410:20 AMProdrug and macromolecule approaches for delivering drugs to the brainDonald MILLERUniversity of Manitoba
    C1510:55 AMUsing Exosomes as Natural Carriers for Nucleic Acid Transfer: An Activity-Composition AnalysisJuliane NGUYENUniversity of Buffalo
    C1611:30 AMReprogrammed Exosomes as a Novel Immunotherapy for Breast Cancer
    Abstract
    Xiaojing SHI
    (Student)
    University of Southern California
    C1711:50 AMDesign and In Vitro/In Vivo Evaluation of LyP-1 Containing SMEDDS for Active Targeting in Breast Cancer Therapy
    Abstract
    Selin Seda TIMUR
    (Postdoc)
    Hacettepe University
  2. Optimizing drug-like properties in discovery and development
    Leader: Prof. Michael HAGEMAN, University of Kansas
    CodeTimeTitlePresenterAffiliation
    C218:30 AMEffect of protein binding on hepatic clearance, intracellular concentration and IC50 predictionsKen BROUWERBioIVT
    C229:05 AMSolubility, biopharmaceutical profiling and formulate-ability: computational tools for assessment during the drug discovery stageChristel BERGSTRÖM
    Uppsala University
    C239:40 AMDodecylated and non-dodecylated polycations as promising siRNA complexing agents for skin diseases treatment
    Abstract
    Marcelo KRAVICZ
    (Student)
    University of Sao Paulo
    10:00 AMTea break
    C2410:20 AMOptimizing for developability and maximizing oral exposure in discoveryMichael HAGEMANUniversity of Kansas
    C2510:55 AMProcessing-induced phase transformationsRaj SURYANARAYANANUniversity of Minnesota
    C2611:30 AMCharacterization of the PEGylated-Functional Upstream Domain Peptide (PEG-FUD): a Potent Fibronectin Assembly Inhibitor with Potential as an Anti-fibrotic Therapeutic
    Abstract
    Pawel ZBYSZYNSKI
    (Student)
    University of Wisconsin-Madison
    C2711:50 AMChloroquine Nanoparticles Improve Biodistribution and Sensitize Pancreatic Cancer to Oxaliplatin and Radiation Therapy
    Abstract
    Richard SLEIGHTHOLM
    (Student)
    University of Nebraska Medical Center
  3. Stability and formulation of biomolecules: Proteins and vaccines
    Leader: Prof. Christian SCHÖNEICH, University of Kansas
    CodeTimeTitlePresenterAffiliation
    C318:30 AMThe ever increasing complexity of protein degradation pathwaysChristian SCHÖNEICHUniversity of Kansas
    C329:05 AMForced degradation of biologicals: why, how and wowWim JISKOOTLeiden University
    C339:40 AMCationic microparticle carrier system as adjuvant approach for pandemic influenza vaccines; proof-of-principle with adsorbed whole inactivated H5N1 influenza
    Abstract
    Celine LEMOINE
    (Student)
    University of Geneva
    10:00 AMTea break
    C3410:20 AMBiosimilarity under stress: a forced degradation study of Remicade and RemsimaAnna SCHWENDEMANUniversity of Michigan
    C3510:55 AMSynthetic high-density lipoprotein nanodiscs for personalized vaccination against glioblastoma multiforme
    Abstract
    Lindsay SCHEETZ
    (Student)
    University of Michigan
    C3611:15 AMFunctional evaluation of mucoadhesive liposome aiming oral delivery of peptide drugs
    Abstract
    Keiko MINAMI
    (Student)
    Setsunan University
    C3711:35 AMSynthesis of functionalised dendritic silica nanoparticles for delivery of anti-diabetic peptide
    Abstract
    Muhammad Mustafa ABEER
    (Student)
    University of Queensland
  4. Application of computational analysis in drug discovery and development
    Leader: Prof. Yu Zong CHEN, National University of Singapore
    CodeTimeTitlePresenterAffiliation
    C418:30 AMArtificial Intelligence and Drug DiscoveryYu Zong CHENNational University of Singapore
    C429:15 AMComputational strategies in search for drug design scaffolds from natural productsHabibah A WAHABUniversiti Sains Malaysia
    10:00 AMTea break
    C4310:20 AMHigh-Content Analysis of Constitutive Androstane Receptor Nuclear Translocation Accurately Identifies Physiologically-Relevant Activators
    Abstract
    Bryan MACKOWIAK
    (Student)
    University of Maryland
    C4410:40 AMComputational modelling of protein-ligand interactions, applied to ligand discovery and function mechanism studiesHao FANBioinformatics Institute, A*STAR
    C4511:25 AMDevelopment of Novel Method to Analyze Transcriptome Profile DataTadahaya MIZUNOUniversity of Tokyo
  5. Population pharmacokinetic modeling and its clinical application
    Leader: Prof. Paul Chi Lui HO, National University of Singapore
    CodeTimeTitlePresenterAffiliation
    C518:30 AMFull Covariates Modelling using Random effects to overcome the bias of covariate selectionHwi-yeol YUNChungnam National University
    C529:05 AMPopulation Pharmacokinetic (PK) - Pharmacogenomic (PG) - Pharmacodynamic (PD) modeling of inhaled budesonide/formoterol combination in Korean asthmatics
    Abstract
    Junyeong KIM (Student)Chungnam National University
    C539:25 AMR for PK simulationCheng-Cai TANGLilly Centre for Clinical Pharmacology Pte Ltd
    10:00 AMTea break
    C5410:20 AMModern tools to enhance clinical utility of modelling and simulationLai-San THAMLily Centre for Clinical Pharmacology Pte Ltd
    C5510:55 AMIdentifying clinically relevant sources of variability: The clopidogrel challengeStephan SCHMIDTUniversity of Florida
    C5611:30 AMDried blood spots for population pharmacokinetic studies of antiepileptic drugs and phenotyping drug resistant epilepsyPaul Chi Lui HONational University of Singapore
  6. Mechanistic and quantitative modeling in pharmacology and toxicology
    Leader: Prof. Eric Chun Yong CHAN, National University of Singapore
    CodeTimeTitlePresenterAffiliation
    C618:30 AMIntroduction on mechanistic and quantitative modeling in pharmacology and toxicologyEric CHANNational University of Singapore
    C629:00 AMDevelopment, validation and application of model to guide complex injectable drug-combination productsRodney HOUniversity of Washington
    C639:40 AMA comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically-based pharmacokinetic modelling
    Abstract
    Fabian JUNG (Student)Goethe University Frankfurt
    10:00 AMTea break
    C6410:20 AMMechanistic modeling to evaluate bile acid-mediated drug-induced liver injury and hepatic transporter interactionsKim BROUWERUniversity of North Carolina Chapel Hill
    C6611:00 AMExtended pharmacokinetic model of the rabbit eye for intravitreal and intracameral injections of macromolecules: quantitative analysis of anterior and posterior elimination pathways
    Abstract
    Marko LAMMINSALO (Student)University of Eastern Finland
    C6711:20 AMIntegrating host-pathogen interactions: A systems-based approach to address antimicrobial resistanceGauri RAOUniversity of North Carolina Chapel Hill