Program Schedule (2018)

Venue: Kent Ridge Guild House

Time	Event
2:00 PM - 4:30 PM	Registration
5:00 PM - 5:15 PM	Welcome address by Prof. Kenneth AUDUS Chair, Globalization of Pharmaceutics Education Network Professor and Dean, School of Pharmacy University of Kansas
5:15 PM - 5:30 PM	Opening remarks by Guest of Honour Prof. Freddy BOEY Senior Vice President (Graduate Education & Research Translation) National University of Singapore
5:30 PM - 6:30 PM	Keynote Lecture by Prof. Patrick J. CASEY Professor and Senior Vice Dean, Research Duke-NUS Medical School
6:30 PM - 8:00 PM	Welcome Reception

Venue: Shaw Foundation Alumni House

• Podium session 1: Nanoparticles in drug delivery

  Code	Time	Title	Presenter
  S1	8:00 AM	Young´s moduli of gelatin nanoparticles and how their mechanical properties influence the in vitro fate Abstract	Agnes-Valencia WEIß
  S2	8:20 AM	Isolation of exosomes for drug delivery applications Abstract	Britta HETTICH
  S3	8:40 AM	Synthesis, characterization, and in vitro and in vivo evaluation of biodegradable silica nanoparticles Abstract	Pouya HADIPOUR
  S4	9:00 AM	The application of light scattering techniques to investigate surface distribution of cell-penetrating peptides on polymeric nanoparticles Abstract	Sarah STRECK
  	9:20 AM	Coffee Break and Poster Session I

• Podium session 2: Lipid-based drug delivery

  Code	Time	Title	Presenter
  S5	10:10 AM	Tetraether liposomes loaded with hypericin for photodynamic therapy of ovarian cancer cells Abstract	Nikola PLENAGL
  S6	10:30 AM	Improved oral bioavailability by supersaturated silica-lipid hybrid formulations Abstract	Hayley SCHULTZ
  S7	10:50 AM	A digestion/permeation model based on artificial membranes for studies of performance of lipid-based formulations Abstract	Oliver HEDGE
  S8	11:10 AM	Cyclodextrin complexation as a tool to allow repurposing of chlorpromazine for treatment of acute myeloid leukemia Abstract	Zhiqiang WANG
  S9	11:30 AM	Fabrication of 3D-printed biocompatible hydrogel patch for the local delivery of PEGylated liposomal doxorubicin Abstract	Jin LIU
  	11:50 AM	Lunch

• Podium session 3: Drug delivery and Formulation

  Code	Time	Title	Presenter
  S10	1:10 PM	Hydrogels releasing nucleic acid-loaded polyplexes Abstract	Lies FLIERVOET
  S11	1:30 PM	Bioresponsive self-assembled DNA hydrogels for antimicrobial peptide loading and therapy Abstract	Sybil OBUOBI
  S12	1:50 PM	Inkjet-based 3D printing of solid oral dosage manufacturing Abstract	Koyel SEN
  S13	2:10 PM	Triple HIV drug combination and lipid excipients form stable solid state interactions leading to an ordered matrix for enhanced drug deliveryAbstract	Jesse YU
  S14	2:30 PM	Treatment with vernix caseosa based formulation alters the skin lipid composition of regenerated stratum corneum Abstract	Walter BOITEN
  	2:50 PM	Coffee Break and Poster Session II

• Podium session 4: Drug delivery and Formulation

  Code	Time	Title	Presenter
  S15	3:40 PM	Probing compression and storage induced surface crystallization with rapid multi-modal nonlinear optical imaging Abstract	Dunja NOVAKOVIC
  S16	4:00 PM	Probing miscibility and mobility in lyophilized protein formulations using solid-state nuclear magnetic resonance spectroscopy Abstract	Ashley LAY
  S17	4:20 PM	Investigation of drug dissolution and absorption from low-density inhalation budesonide formulations in a cell culture integrating impactor system Abstract	Ursula THORMANN
  S18	4:40 PM	Impact of amorphization strategy and drug loading on dissolution rate of spray dried indomethacin Abstract	Yongquan LI

• GPEN networking event: Cultural Night

  Time	Event
  5:00 PM	Bus transfer to Satay by the Bay - Gardens by the Bay
  6:00 PM	Cultural Night @ Satay by the Bay - Gardens by the Bay

Venue: Shaw Foundation Alumni House

• Podium session 5: Targeted drug delivery and pharmacogenomics

  Code	Time	Title	Presenter
  S20	8:00 AM	Development of a nanostructured RNA/DNA adjuvant targeting Toll-like receptor 7/8 Abstract	Fusae KOMURA
  S21	8:20 AM	Tumor microenvironment sub-type immune cells precise delivery by extravasation-oriented targeting-ligand reemerge strategy: the first step on the way to effective cancer immunotherapy Abstract	Tianqi WANG
  S22	8:40 AM	Characterizing patient-derived induced neural stem cells as a drug delivery platform for glioblastoma Abstract	Shaye HAGLER
  S23	9:00 AM	Genome-wide analyses associate variants in Rho GTPase signaling pathways with microtubule targeting agent-induced sensory peripheral neuropathy Abstract	Katherina CHUA
  S24	9:20 AM	Effect of ABCB1 haplotypes on tacrolimus disposition in heart transplant recipients Abstract	Kris ORESCHAK
  	9:40 AM	Coffee Break and Poster Session I

• Podium session 6: Pharmacokinetics

  Code	Time	Title	Presenter
  S25	10:30 AM	Metabolomic/proteomic analysis of orphan transporter monocarboxylate transporter 6 (MCT6): Evidence of a role in lipid metabolism Abstract	Robert JONES
  S26	10:50 AM	Quantification of postmenopausal osteoporosis population: An system pharmacology approach using bisphosphonates. Abstract	Yi Ting (Kayla) LIEN
  S27	11:10 AM	Investigation of endogenous substrates of OCT2 as surrogate biomarker for the prediction of transporter-mediated drug-drug interaction Abstract	Takeshi MIYAKE
  S28	11:30 AM	Quantification of 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids helps to understand the intraluminal drug behavior following the oral intake of Sporanox® Abstract	Philippe BERBEN
  S29	11:50 AM	A co-perfused in vivo absorption model to probe the simultaneous digestion and drug absorption process from lipid-based formulations Abstract	Estelle SUYS
  	12:10 AM	Lunch

• Podium session 7: Proteomics and biomarkers

  Code	Time	Title	Presenter
  S30	1:30 PM	Quantitative proteomics-based characterization of apical and basolateral membrane protein localization in human retinal pigmental epithelial cells Abstract	Kazuki SATO
  S31	1:50 PM	Isolation and characterization of liver-derived exosomes by liver marker protein asialoglycoprotein-1 (ASGR1) and proteomic Analysis Abstract	Laura DRBOHLAV
  S32	2:10 PM	Fibrillation kinetics of therapeutic peptides by hydrogen/deuterium exchange mass spectrometry (HDX-MS) Abstract	Harshil RENAWALA
  S33	2:30 PM	Evaluation of paraoxonase-1 activity in the synovial fluid of osteoarthritis patients Abstract	Daniel AKATWIJUKA
  	2:50 PM	Coffee Break and Poster Session II

• Podium session 8: Signaling pathways

  Code	Time	Title	Presenter
  S34	3:40 PM	HSPG2/perlecan as a therapeutic target in metastatic cancers Abstract	Vidhi KHANNA
  S35	4:00 PM	Reversal of fatty liver by peripheral CB1 receptor blockade Is SIRT1/PPARα dependent Abstract	Shahar AZAR
  S36	4:20 PM	Impact of the canonical Wnt signaling pathway on blood-brain barrier (BBB) phenotype Abstract	Marlyn LAKSITORINI

• GPEN networking event: Gala Dinner

  Time	Event
  4:40 PM	Bus transfer to Flyer Event Hall - Singapore Flyer
  6:30 PM	Gala Dinner @ Singapore Flyer

Venue: S16, Faculty of Science

Time	Event
8:00 AM - 8:20 AM	Arrival and luggage storage
8:30 AM - 12:10 PM	Short courses 1-6 (details below)
12:20 PM - 1:30 PM	Lunch
1:30 PM - 2:00 PM	Closing and award ceremony

The following concurrent short courses will be available, with exact venue to be announced at a later date.

1. Challenges and progress in drug delivery: Prodrugs and macromolecules
   Leaders:
   Prof. Teruna SIAHAAN, University of Kansas
   Prof. Donald MILLER, University of Manitoba
   *Titles to-be-confirmed (TBC)
   

   Code	Time	Title	Presenter	Affiliation
   C11	8:30 AM	General overview of approaches for prodrug and macromolecule delivery across biological barriers	Teruna SIAHAAN	University of Kansas
   C12	9:05 AM	Prodrug approaches for oral absorption	Patrick AUGUSTIJNS	KU Leuven
   C13	9:40 AM	Nanocage therapeutics mediating immune checkpoint blockade awakens immunity against cancer with an immunogenic cell death (ICD)-inducing doxorubicin prodrug Abstract	Na Kyeong LEE (Student)	Seoul National University
   	10:00 AM	Tea break
   C14	10:20 AM	Prodrug and macromolecule approaches for delivering drugs to the brain	Donald MILLER	University of Manitoba
   C15	10:55 AM	Using Exosomes as Natural Carriers for Nucleic Acid Transfer: An Activity-Composition Analysis	Juliane NGUYEN	University of Buffalo
   C16	11:30 AM	Reprogrammed Exosomes as a Novel Immunotherapy for Breast Cancer Abstract	Xiaojing SHI (Student)	University of Southern California
   C17	11:50 AM	Design and In Vitro/In Vivo Evaluation of LyP-1 Containing SMEDDS for Active Targeting in Breast Cancer Therapy Abstract	Selin Seda TIMUR (Postdoc)	Hacettepe University

2. Optimizing drug-like properties in discovery and development
   Leader: Prof. Michael HAGEMAN, University of Kansas

   Code	Time	Title	Presenter	Affiliation
   C21	8:30 AM	Effect of protein binding on hepatic clearance, intracellular concentration and IC50 predictions	Ken BROUWER	BioIVT
   C22	9:05 AM	Solubility, biopharmaceutical profiling and formulate-ability: computational tools for assessment during the drug discovery stage	Christel BERGSTRÖM	Uppsala University
   C23	9:40 AM	Dodecylated and non-dodecylated polycations as promising siRNA complexing agents for skin diseases treatment Abstract	Marcelo KRAVICZ (Student)	University of Sao Paulo
   	10:00 AM	Tea break
   C24	10:20 AM	Optimizing for developability and maximizing oral exposure in discovery	Michael HAGEMAN	University of Kansas
   C25	10:55 AM	Processing-induced phase transformations	Raj SURYANARAYANAN	University of Minnesota
   C26	11:30 AM	Characterization of the PEGylated-Functional Upstream Domain Peptide (PEG-FUD): a Potent Fibronectin Assembly Inhibitor with Potential as an Anti-fibrotic Therapeutic Abstract	Pawel ZBYSZYNSKI (Student)	University of Wisconsin-Madison
   C27	11:50 AM	Chloroquine Nanoparticles Improve Biodistribution and Sensitize Pancreatic Cancer to Oxaliplatin and Radiation Therapy Abstract	Richard SLEIGHTHOLM (Student)	University of Nebraska Medical Center

3. Stability and formulation of biomolecules: Proteins and vaccines
   Leader: Prof. Christian SCHÖNEICH, University of Kansas

   Code	Time	Title	Presenter	Affiliation
   C31	8:30 AM	The ever increasing complexity of protein degradation pathways	Christian SCHÖNEICH	University of Kansas
   C32	9:05 AM	Forced degradation of biologicals: why, how and wow	Wim JISKOOT	Leiden University
   C33	9:40 AM	Cationic microparticle carrier system as adjuvant approach for pandemic influenza vaccines; proof-of-principle with adsorbed whole inactivated H5N1 influenza Abstract	Celine LEMOINE (Student)	University of Geneva
   	10:00 AM	Tea break
   C34	10:20 AM	Biosimilarity under stress: a forced degradation study of Remicade and Remsima	Anna SCHWENDEMAN	University of Michigan
   C35	10:55 AM	Synthetic high-density lipoprotein nanodiscs for personalized vaccination against glioblastoma multiforme Abstract	Lindsay SCHEETZ (Student)	University of Michigan
   C36	11:15 AM	Functional evaluation of mucoadhesive liposome aiming oral delivery of peptide drugs Abstract	Keiko MINAMI (Student)	Setsunan University
   C37	11:35 AM	Synthesis of functionalised dendritic silica nanoparticles for delivery of anti-diabetic peptide Abstract	Muhammad Mustafa ABEER (Student)	University of Queensland

4. Application of computational analysis in drug discovery and development
   Leader: Prof. Yu Zong CHEN, National University of Singapore

   Code	Time	Title	Presenter	Affiliation
   C41	8:30 AM	Artificial Intelligence and Drug Discovery	Yu Zong CHEN	National University of Singapore
   C42	9:15 AM	Computational strategies in search for drug design scaffolds from natural products	Habibah A WAHAB	Universiti Sains Malaysia
   	10:00 AM	Tea break
   C43	10:20 AM	High-Content Analysis of Constitutive Androstane Receptor Nuclear Translocation Accurately Identifies Physiologically-Relevant Activators Abstract	Bryan MACKOWIAK (Student)	University of Maryland
   C44	10:40 AM	Computational modelling of protein-ligand interactions, applied to ligand discovery and function mechanism studies	Hao FAN	Bioinformatics Institute, A*STAR
   C45	11:25 AM	Development of Novel Method to Analyze Transcriptome Profile Data	Tadahaya MIZUNO	University of Tokyo

5. Population pharmacokinetic modeling and its clinical application
   Leader: Prof. Paul Chi Lui HO, National University of Singapore

   Code	Time	Title	Presenter	Affiliation
   C51	8:30 AM	Full Covariates Modelling using Random effects to overcome the bias of covariate selection	Hwi-yeol YUN	Chungnam National University
   C52	9:05 AM	Population Pharmacokinetic (PK) - Pharmacogenomic (PG) - Pharmacodynamic (PD) modeling of inhaled budesonide/formoterol combination in Korean asthmatics Abstract	Junyeong KIM (Student)	Chungnam National University
   C53	9:25 AM	R for PK simulation	Cheng-Cai TANG	Lilly Centre for Clinical Pharmacology Pte Ltd
   	10:00 AM	Tea break
   C54	10:20 AM	Modern tools to enhance clinical utility of modelling and simulation	Lai-San THAM	Lily Centre for Clinical Pharmacology Pte Ltd
   C55	10:55 AM	Identifying clinically relevant sources of variability: The clopidogrel challenge	Stephan SCHMIDT	University of Florida
   C56	11:30 AM	Dried blood spots for population pharmacokinetic studies of antiepileptic drugs and phenotyping drug resistant epilepsy	Paul Chi Lui HO	National University of Singapore

6. Mechanistic and quantitative modeling in pharmacology and toxicology
   Leader: Prof. Eric Chun Yong CHAN, National University of Singapore

   Code	Time	Title	Presenter	Affiliation
   C61	8:30 AM	Introduction on mechanistic and quantitative modeling in pharmacology and toxicology	Eric CHAN	National University of Singapore
   C62	9:00 AM	Development, validation and application of model to guide complex injectable drug-combination products	Rodney HO	University of Washington
   C63	9:40 AM	A comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically-based pharmacokinetic modelling Abstract	Fabian JUNG (Student)	Goethe University Frankfurt
   	10:00 AM	Tea break
   C64	10:20 AM	Mechanistic modeling to evaluate bile acid-mediated drug-induced liver injury and hepatic transporter interactions	Kim BROUWER	University of North Carolina Chapel Hill
   C66	11:00 AM	Extended pharmacokinetic model of the rabbit eye for intravitreal and intracameral injections of macromolecules: quantitative analysis of anterior and posterior elimination pathways Abstract	Marko LAMMINSALO (Student)	University of Eastern Finland
   C67	11:20 AM	Integrating host-pathogen interactions: A systems-based approach to address antimicrobial resistance	Gauri RAO	University of North Carolina Chapel Hill